Science & Technology
MANF is a highly potent, neurotrophic factor currently in pre-clinical development for the treatment of several apoptosis-related disorders. Coming after other selective neurotrophic factors such as GDNF, Neurturin, NGF, and others, MANF’s discovery protocols, utilizing our proprietary PhenoGuard Protein Discovery Engine were designed to identify a molecule that would be highly selective for dopamine producing neurons of the Substantia Nigra. MANF represents a new family of neurotrophic factors with mechanisms of action fundamentally differentiated from its predecessors.
MANF is an endogenous, highly-conserved, ubiquitously expressed and highly potent secreted human growth factor up-regulated in the adaptive pathway of the Unfolded Protein Response resulting in the prevention of apoptosis. This cell death is associated with several devastating human diseases and injury related disorders. By mediating this critical biological process, MANF is indicated for the treatment of several poorly served medical conditions, including Parkinson’s disease, Ischemic Heart Disease and Traumatic Brain Injury.