Science & Technology
Proliferation of DA Neuron by of two PhenoGuard
Astrocytes are brain cells that make up a large portion of the cells in the Central Nervous System. Generally speaking, the function of astrocytes is support neurons throughout their development. The support they provide is localized, which means that astrocytes from a specific brain region act more powerfully on neurons from that particular brain region than from any other. Astrocytes mediate three critical brain functions:
1. Neuroprotection: Helping to protect neurons from death
2. Neurogenesis: Helping to generate new neurons from stem cells
3. Synaptogenesis: Helping to establish connections between neurons
Bushong et al, 2003. J Comp Neurol 462: 451-461
Astrocytes perform these tasks by producing and secreting molecules that affect neurons. Using our proprietary method, we are able to identify these highly relevant proteins with biological activity for the protection of neurons and other cells associated with the treatment of devastating human disorders. The first drug candidate identified from this platform is MANF.