Alzheimer's Disease Diagnostics SAB

Jeffrey L. Cummings, M.D., Sc.D.

Dr. Cummings is a leading expert in neuropsychiatry of neurologic disorders, biomarkers for neurodegenerative diseases, and an experienced clinical trialist with expertise in trial design and analysis, global trial implementation, and trial outcome measures. He is Director, Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, Nevada and Cleveland, Ohio. Additionally he is the Camille and Larry Ruvo Chair of the Neurological Institute of Cleveland Clinic and Professor of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. Dr. Cummings is the author of the Neuropsychiatric Inventory (NPI), which is the most commonly used tool for clinical trials characterizing behavioral disturbances in dementia syndromes.

Dr. Cummings’ research and leadership contributions in the field of Alzheimer’s disease have been recognized through the Henderson Award of the American Geriatrics Society (2006), the Research Award of the John Douglas French Alzheimer’s Research Foundation (2008), and the Ronald and Nancy Reagan Research Award of the national Alzheimer’s Association (2008). In 2010, he received the Legacy Award from the Ticki Wilkerson-Kassel Movement Therapy Foundation and was honored by the American Association of Geriatric Psychiatry with their Distinguished Scientist Award. In 2011, he was awarded an honorary Doctor of Science by his alma mater, The University of Wyoming and was recognized for his “Lifetime of Medical Achievement” in Healthcare Headliners, a special publication of Las Vegas Inc. magazine (September 2011).

Dr. Cummings was featured in GQ (June 2009), Vogue (September 2009) and Vanity Fair (September 2009) as a “Rockstar of Science.” Dr. Cummings was formerly Professor of Neurology and Psychiatry at UCLA, director of the Mary S. Easton Center for Alzheimer’s Disease Research at UCLA, and director of the Deane F. Johnson Center for Neurotherapeutics at UCLA. He is past president of the Behavioral Neurology Society and of the American Neuropsychiatric Association. Dr. Cummings has authored or edited over 38 books and published 650 peer- reviewed papers.

Robert A. Stern, Ph.D.

Dr. Stern’s major focus of research expertise is on the long-term effects of repetitive brain trauma in athletes, including the neurodegenerative disease, Chronic Traumatic Encephalopathy (CTE). He is a Professor of neurology, neurosurgery, anatomy and neurobiology at Boston University School of Medicine, Director of the Clinical Core of the Boston University Alzheimer’s Disease Center, and Director of Clinical Research for the CTE Center at Boston University. Both the NIH and the Department of Defense have funded his work on developing methods of detecting and diagnosing CTE during life, as well as examining potential genetic and other risk factors for this disease. Dr. Stern’s other major areas of funded research include the assessment and treatment of Alzheimer’s disease, the cognitive effects of chemotherapy in the elderly, thyroid-brain relationships, and driving and dementia. He has published on various aspects of cognitive assessment and is the senior author of many widely used neuropsychological tests, including the Neuropsychological Assessment Battery (NAB).

Dr. Stern was formerly on the faculty at University of North Carolina, where he was the Associate Director of the NIMH-funded Mental Health Clinical Research Center, and Director of the Neurobehavioral Assessment Core. He was also on the faculty at Brown Medical School, where he was Associate Professor of Psychiatry and Neurology, as well as Director of Neuropsychology and the Memory and Cognitive Assessment Program at Rhode Island Hospital. Dr. Stern has received several NIH and other national grants and has published over 250 journal articles, chapters, and abstracts. He is a Fellow of both the American Neuropsychiatric Association and the National Academy of Neuropsychology. He is on several editorial boards and serves on the Medical and Scientific Advisory Boards of the MA/NH Chapter of the Alzheimer’s Association and the Sports Legacy Institute. Dr. Stern is also a member of the Mackey-White Traumatic Brain Injury Committee of the NFL Players Association. He has testified before the U.S. Senate Special Committee on Aging and frequently appears in national and international print and broadcast media for his work on CTE and AD.

Paula T. Trzepacz, M.D.

Dr. Trzepacz is an international expert in delirium, with extensive psychiatric clinical experience in the assessment and management of neurological disorders in Geriatrics Psychiatry, Neuropsychiatry and Psychosomatic Medicine including delirium, dementias and traumatic brain injury. She is a Clinical Professor of Psychiatry at Indiana University School of Medicine, on the Clinical Faculty at the University of Mississippi Medical School, and an Adjunct Professor of Psychiatry at Tufts University School of Medicine. Dr. Trzepacz has been a principal investigator or research collaborator for numerous international and NIH-funded projects, including a genomics study of post-operative delirium at Duke University Medical School and research in ICU delirium at Indiana University School of Medicine.

Most recently Dr. Trzepacz was a Senior Medical Fellow at Eli Lilly and Company (“Lilly”) focused on amyloid assessment in evaluation of cognitive impairment and the scientific exploration of the relationship of a variety of biomarkers across the continuum of Alzheimer’s disease. Her role at Lilly neuroscience also included registration experience, Phase 2 through Phase 4 clinical programs, and leading the Phase 2 program on mibampator for agitation and aggression in AD. She serves on the editorial boards of the Journal of Neuropsychiatry and Clinical Neurosciences, General Hospital Psychiatry, and Psychosomatics. Additionally, Dr. Trzepacz has published and lectured extensively on delirium and neuropsychiatry. She was President of the Academy of Psychosomatic Medicine (APM) from 2004-2005, and President of the American Neuropsychiatric Association (ANPA) from 2009-2011, and is a Fellow of both organizations. Dr. Trzepacz is the recipient of a number of honors and awards, including the 1997 Research Award from APM, and was listed in four editions of Best Doctors in America.